Necroptosis is involved in cardiac cell death induced by chemical ischemia
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منابع مشابه
Sorafenib-induced defective autophagy promotes cell death by necroptosis
Autophagy is one of the main cytoprotective mechanisms that cancer cells deploy to withstand the cytotoxic stress and survive the lethal damage induced by anti-cancer drugs. However, under specific conditions, autophagy may, directly or indirectly, induce cell death. In our study, treatment of the Atg5-deficient DU145 prostate cancer cells, with the multi-tyrosine kinase inhibitor, sorafenib, i...
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Introduction Eosinophils are continually targeted in allergic airway inflammatory disease therapies. The presence of their granules in airway tissues remains unexplained, yet implies the involvement of necrosis. The latter’s definition has evolved into a highly regulated and distinct signalling pathway leading to physiological inflammation, known as necroptosis. Even though necroptosis is a rec...
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Macroautophagy (autophagy) is a conserved cell survival pathway that catabolizes damaged proteins and organelles to maintain homeostasis and serves as a potential source of nutrients. Under basal cell conditions, cytosolic contents are sequestered by the autophagosome and ultimately delivered to the lysosome for degradation. The degradative process can in turn be upregulated in response to mult...
متن کامل[Autophagy is involved in 6-OHDA-induced dopaminergic cell death].
OBJECTIVE To study the role of autophagy in the death of dopaminergic neurons induced by 6-hydroxydopamine (6-OHDA). METHODS Rat models of Parkinson disease (PD) were established by stereotaxic administration of 6-OHDA (8 μg) into the unilateral substantia nigra par compact (SNpc). Autophagosomes in the SNpc were observed with transmission electron microscopy (TEM), and the expression of auto...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.1238.24